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KMID : 1035620150030030187
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Allergy Asthma & Respiratory Disease
2015 Volume.3 No. 3 p.187 ~ p.193
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Seasonal and regional variations in the causes of anaphylaxis in Korean adults
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이연경:Lee Yeon-Kyung
김미경:Kim Mi-Kyeong/강혜련:Kang Hye-Ryun/김태범:Kim Tae-Bum/손성욱:Sohn Seong-Wook/박혜경:Park Hye-Kyung/고영일:Koh Young-Il/장광천:Jang Gwang-Cheon/김철우:Kim Cheol-Woo/지영구:Jee Young-Koo/허규영:Hur Gyu-Young/김주희:Kim Joo-Hee/김상헌:Kim Sang-Heon/최길순:Choi Gil-Soon/이수걸:Lee Soo-Keol/박해심:Park Hae-Sim/예영민:Ye Young-Min
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Abstract
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Purpose: To investigate whether causes of anaphylaxis vary according to regions and seasons in Korean adults.
Methods: Based on previous retrospective studies of anaphylaxis between 2007 and 2011 at the 15 university hospitals. Regions were classified into 4 groups: region I, Seoul; region II, Gyeonggi; region III, Chungcheong; and region IV, Chonnam and Busan. The cases induced by 5 major allergens including drugs, food, bee sting, radiocontrast media, and exercise, were analyzed in the present study.
Results: Among a total of 1,661 cases reported (53% male, 45.9±16.0 years), 367 (22.2%), 706 (42.5%), 319 (19.2%), and 269 cases (16.2%) were enrolled in regions I, II, III, and IV, respectively. Of the 5 major allergens, drugs (37.3%) were the most frequently reported, followed by food (25.7%), bee sting (17.9%), radiocontrast media (12.9%), and exercise (6.2%). There was no significant difference in the total occurrence of anaphylaxis in 4 seasons (374 in spring, 460 in summer, 460 in autumn, and 367 in winter). Multiple logistic regression analysis revealed that drug-induced anaphylaxis was significantly associated with the winter season (odds ratio [OR] 1.0 vs. OR 0.597, P<0.05 for spring; OR 1.0 vs. OR 0.481, P<0.01 for summer; OR 1.0 vs. OR 0.653, P<0.05 for autumn). Food-associated anaphylaxis was mainly reported in region I, whereas the frequency of insect sting was relatively higher in regions II, III, and IV than in region I. Older age and female gender were significantly associated with drug-induced anaphylaxis.
Conclusion: Specific causative allergens of anaphylaxis in adults may vary according to age, gender, region, and season in Korea.
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KEYWORD
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Anaphylaxis, Adult, Etiology, Seasons, Geographic locations
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